David Y Thomas

Title: David Y Thomas: Innovator in Protein Folding Technologies

Introduction

David Y Thomas is a prominent inventor based in Montreal, Canada. He has made significant contributions to the field of protein folding and trafficking disorders. With a total of 3 patents, his work has the potential to impact various biomedical applications.

Latest Patents

One of his latest patents is a method for folding unfolded proteins. This invention relates to methods of treating and diagnosing protein trafficking disorders and controlling secretory protein production. The method involves exposing an unfolded protein to a biological preparation comprising ERp57 in combination with calnexin or calreticulin under conditions that allow for the proper folding of the protein.

Another notable patent focuses on methods for screening UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity and nucleic acid encoding for UGGT. This invention outlines a method for determining the effect of a test sample on UGGT activity. The process includes exposing an acceptor substrate of UGGT to a labeled donor in the presence of the test sample and UGGT, followed by detecting the amount of donor transferred to the acceptor substrate. This method can identify whether a test sample acts as a UGGT stimulator or inhibitor.

Career Highlights

David Y Thomas is affiliated with the National Research Council of Canada, where he continues to advance research in protein folding technologies. His innovative approaches have garnered attention in the scientific community.

Collaborations

He has collaborated with notable colleagues, including Daniel C Tessier and John J M Bergeronon, further enhancing the impact of his research.

Conclusion

David Y Thomas is a key figure in the field of protein folding, with a focus on developing methods that could revolutionize the treatment of protein trafficking disorders. His contributions are paving the way for future advancements in biomedical research.