David S Thiriot

Title: David S Thiriot: Innovator in Aluminum Hydroxyphosphate Adjuvant Preparation

Introduction

David S Thiriot is a notable inventor based in Harleysville, PA (US). He has made significant contributions to the field of vaccine formulation through his innovative methods for preparing aluminum hydroxyphosphate adjuvants. His work is particularly relevant in the context of large-scale manufacturing processes.

Latest Patents

Thiriot holds a patent for a "Method for preparation of aluminum hydroxyphosphate adjuvant." This invention relates to methods for preparing amorphous aluminum hydroxyphosphate. The process involves co-mixing an aluminum salt and a phosphate solution at a constant ratio in the presence of a buffer. An excess of the phosphate solution is preferably used to act as a buffer, maintaining a constant pH during the reaction without the need for active adjustment. This method is especially applicable for the large-scale manufacturing of aluminum phosphate adjuvant, which is used in vaccine formulations, particularly those that include a protein or saccharide antigen.

Career Highlights

David S Thiriot is associated with Merck Sharp & Dohme Corporation, a leading company in the pharmaceutical industry. His work at Merck has allowed him to focus on innovative solutions that enhance vaccine efficacy and safety.

Collaborations

Thiriot has collaborated with notable colleagues such as Patrick L Ahl and Jayme L Cannon. These collaborations have contributed to the advancement of research and development in vaccine adjuvants.

Conclusion

David S Thiriot's contributions to the field of vaccine formulation through his patented methods for aluminum hydroxyphosphate adjuvant preparation highlight his role as an important innovator. His work continues to impact the pharmaceutical industry positively.