David S Shames

Title: The Innovative Contributions of David S Shames

Introduction

David S Shames is a notable inventor based in Dallas, Texas, who has made significant strides in the field of genetic research. With a total of three patents to his name, Shames focuses on innovative methods aimed at modulating gene expression, which has promising implications for the treatment of various diseases, including cancer.

Latest Patents

Among Shames' latest patents is the innovation titled "Modulation of gene expression by oligomers targeted to chromosomal DNA." This patent describes a method for selectively increasing the synthesis of a target transcript of a gene in mammalian cells by utilizing a polynucleotide oligomer that is complementary to a specific promoter region within the gene. This method holds great potential for advancing genetic therapy.

Another significant invention by Shames is "Interfering RNAs against the promoter region of P53." This invention pertains to the inhibition of p53 gene transcription by using double-stranded RNAs to interfere with its promoter activity. The application of these inhibitory RNAs presents a novel approach to cancer treatment by targeting p53, a critical gene involved in regulating the cell cycle and maintaining genomic stability.

Career Highlights

David S Shames is associated with the University of Texas System, a distinguished institution renowned for its contributions to research and innovation in various scientific fields. His work within this esteemed system exemplifies the intersection of academic research and practical application in the realm of genetic innovations.

Collaborations

Throughout his career, Shames has collaborated with fellow researchers and inventors, including David R Corey and John Dorrance Minna. These collaborations have been instrumental in furthering the understanding of gene modulation and enhancing the efficacy of therapeutic interventions for gene-related disorders.

Conclusion

David S Shames stands out as an influential figure in the world of genetic innovation. His contributions through his patents reflect a commitment to advancing medical science and addressing complex challenges in cancer treatment. As research continues to evolve, the impact of Shames’ work is likely to resonate within the scientific community and beyond.