David M Donofrio

Title: **David M. Donofrio: Innovator in Biochemical Analysis and Cell Culturing Technologies**

Introduction

David M. Donofrio is a distinguished inventor based in Rockport, Massachusetts, with a proven track record in developing innovative solutions in the fields of biochemical analysis and cell culturing systems. With two patents to his name, Donofrio continues to make significant contributions to his field, particularly through his latest inventions aimed at enhancing laboratory efficiency and accuracy.

Latest Patents

Donofrio's most recent patents include the following:

1. **Microfiltration Apparatus with Radially Spaced Nozzles**

This invention describes a multiwell apparatus designed for biological and biochemical analysis, facilitating the separate collection of filtrate from each well while preventing cross-contamination. The apparatus incorporates a manifold plate with an array of filtering wells, each equipped with a discharge nozzle that allows for a steady stream of filtrate collection into a receiving multiwell plate. This innovation particularly benefits immunoassays, nucleic acid probe assays, and various test procedures by improving the quantitative collection of samples.

2. **Hollow Fiber Bioreactor Culture System and Method**

This advanced cell culturing system utilizes a hollow fiber cartridge where nutrient-containing medium circulates continuously. Cells are cultivated in the cartridge, allowing for efficient nutrient absorption and waste removal through semipermeable membranes. The system includes various components such as circulating pumps and pH probes, thereby maintaining an optimal environment for cell growth without the need for a conventional nutrient-solution preparation reservoir, simplifying the overall process and minimizing contamination risks.

Career Highlights

David M. Donofrio has achieved considerable recognition in his career while working with W.R. Grace & Co. (Conn.), a company noted for its focus on innovative solutions across various industries. His work has contributed significantly to advancements in laboratory technologies, showcasing his expertise and dedication to innovation.

Collaborations

Throughout his career, Donofrio has collaborated with a number of talented professionals, including William F. Bowers and Scott P. Fulton. These partnerships have likely fueled the development and refinement of his inventive concepts, allowing for shared expertise and resources in advancing technological solutions.

Conclusion

David M. Donofrio stands out as a remarkable inventor whose contributions to microfiltration and cell culturing systems are paving the way for improved methods in scientific research and analysis. His ongoing commitment to innovation reflects the transformative potential of his inventions, solidifying his status as a key figure within the field of biochemical technologies.