David Leonardo

Title: Innovations of David Leonardo

Introduction

David Leonardo is an accomplished inventor based in San Francisco, CA. He holds a total of four patents that contribute significantly to the fields of pharmacology and neurology. His work focuses on developing methods and compositions that aid in the diagnosis and treatment of various diseases.

Latest Patents

One of his latest patents involves a polynucleotide encoding human netrin-1. This patent includes specific netrin proteins, nucleic acids that encode netrin proteins, and hybridization reagents, probes, and primers capable of hybridizing with netrin genes. The methods provided in this patent are designed for screening chemical libraries for lead compounds that can be used as pharmacological agents in the diagnosis or treatment of diseases associated with undesirable cell growth. An exemplary screening method involves forming a mixture that includes a recombinant netrin protein, a natural intracellular netrin protein binding target, and a candidate pharmacological agent. The mixture is incubated under conditions that allow for the selective binding of the netrin protein to the binding target, enabling the detection of specific binding.

Another significant patent by David Leonardo focuses on neurological drug screens. This patent describes compositions for identifying lead compounds that are useful in diagnosing or treating neurological diseases or injuries. The compositions include mixtures of an isolated netrin and an isolated natural netrin receptor, such as Deleted in Colorectal Carcinoma (DCC) and neogenin. The general methods involve incubating a mixture of an isolated mammalian netrin, an isolated natural mammalian netrin receptor, and a candidate pharmacological agent to determine if the agent modulates the binding of the netrin to the receptor.

Career Highlights

David has worked with the University of California, where he has made significant contributions to research and development in his field. His innovative approaches have led to advancements in understanding and treating various medical conditions.

Collaborations

Throughout his career, David has collaborated with notable individuals such as Marc Tessier-Lavigne and Lindsay Hinck. These collaborations have further enhanced the impact of his work in the scientific community.

Conclusion

David Leonardo's contributions to the fields of pharmacology and neurology through his patents and collaborations highlight his role as a significant inventor. His innovative methods and compositions continue to pave the way for advancements in medical research and treatment.