Company Filing History:
Years Active: 1997-2000
Title: David L. Jenish: Innovator in Protein Expression Technologies
Introduction
David L. Jenish is a notable inventor based in Mississauga, Canada. He has made significant contributions to the field of protein expression, holding a total of 3 patents. His work focuses on improving the efficiency and effectiveness of protein production in bacterial host cells.
Latest Patents
One of his latest patents is titled "Method for expression of proteins in bacterial host cells." This invention utilizes an aminopeptidase inhibitor to enhance the expression of heterologous proteins in bacterial hosts, such as Streptomyces. The inhibitor prevents the degradation of these proteins by aminopeptidases, which is crucial for maintaining protein integrity during expression. Another significant patent is "Streptomyces proteases and methods for improved secretion of." This patent identifies a family of proteases that degrade heterologous proteins secreted from Streptomyces cells. The invention includes previously unidentified proteases, such as tripeptidyl aminopeptidase-Streptomyces and others that exhibit specific substrate degradation capabilities. The patent outlines methods to alleviate degradation through selective inhibition of these proteases or by using hosts with impaired protease production.
Career Highlights
David L. Jenish is currently associated with Cangene Corporation, where he continues to advance his research in protein expression technologies. His innovative approaches have the potential to significantly impact the biotechnology industry.
Collaborations
Throughout his career, David has collaborated with notable colleagues, including Daniel Bartfeld and Michael J. Butler. These collaborations have fostered a productive environment for innovation and research.
Conclusion
David L. Jenish is a prominent figure in the field of protein expression, with a focus on enhancing the production of heterologous proteins in bacterial systems. His patents reflect a deep understanding of protease mechanisms and their implications for biotechnology.