Location History:
- London, GB (2010)
- Cambridge, GB (2014 - 2017)
Company Filing History:
Years Active: 2010-2017
Title: The Innovations of David Komander
Introduction
David Komander is a prominent inventor based in Cambridge, GB. He has made significant contributions to the field of biomedical research, particularly in the analysis of ubiquitin polymers. With a total of 3 patents to his name, Komander's work has advanced our understanding of protein regulation and cellular processes.
Latest Patents
One of his latest patents is focused on "Ubiquitin chain analysis." This patent describes a method for analyzing ubiquitin polymers using linkage-specific deubiquitinase enzymes. The invention also provides novel specificities of these deubiquitinase enzymes, which are crucial for understanding protein degradation pathways. Another notable patent is for an "Engineered E2 for increasing the content of free LYS11-linked ubiquitin." This invention presents a chimeric E2 enzyme that comprises a Ubc domain fused to a heterologous ubiquitin binding domain (UBD). The chimeric enzymes developed through this invention may be useful in producing elevated levels of free polyubiquitin.
Career Highlights
David Komander is affiliated with the Medical Research Council, where he conducts his research. His work has been instrumental in elucidating the mechanisms of ubiquitin signaling, which plays a vital role in various cellular functions.
Collaborations
Throughout his career, Komander has collaborated with notable scientists, including Dario Alessi and Ricardo Biondi. These collaborations have further enriched his research and contributed to advancements in the field.
Conclusion
David Komander's innovative work in the field of ubiquitin research has led to significant advancements in our understanding of protein regulation. His contributions continue to influence the scientific community and pave the way for future discoveries.