David John Mead

Title: David John Mead - Innovator in Recombinant Albumin Purification

Introduction

David John Mead is a notable inventor based in Nottingham, GB, who has made significant contributions to the field of biopharmaceuticals. With two patents to his name, he is recognized for his innovative approaches to the purification of recombinant albumin, a critical protein used in various medical applications.

Latest Patents

Mead's latest patents focus on processes for the purification of recombinant albumin. The first patent outlines a method for preparing a highly pure albumin solution, emphasizing a series of intricate chromatographic steps. His method includes positive mode cation exchange chromatography, positive mode anion exchange chromatography, and multiple affinity chromatographies. A significant aspect of this patent is the reduction of nickel content in the final albumin solution to less than 100 ng per gram. Furthermore, his second patent is dedicated to producing recombinant albumin through culturing fungal cells that express a specific coding sequence while minimizing mannosylation, enhancing the quality of the resulting protein.

Career Highlights

David John Mead has had a notable career, having worked with esteemed companies like Novozymes Biopharma and Albumedix. His expertise in biotechnology and protein engineering has paved the way for advances in the production and purification of recombinant proteins, particularly albumin, which is vital in therapeutic treatments.

Collaborations

Throughout his career, Mead has collaborated with talented professionals, including Hendrik Van Urk and Philip Harvey Morton. These collaborations have contributed to his innovative work, bringing together diverse perspectives and expertise in the field of biopharmaceuticals.

Conclusion

David John Mead's contributions to the purification of recombinant albumin have not only advanced the scientific community's understanding of protein purification processes but have also provided valuable methodologies that can enhance therapeutic applications. His patents reflect a deep understanding of biotechnological principles, highlighting his role as an innovator in the field.