David Holmes

Title: Innovations of David Holmes in Microfluidic Systems

Introduction

David Holmes is an accomplished inventor based in Babraham, Cambridge, GB. He has made significant contributions to the field of microfluidics, holding a total of three patents. His work focuses on advancing droplet processing methods and systems, which have important applications in various scientific and medical fields.

Latest Patents

One of his latest patents is titled "Droplet processing methods and systems." This invention outlines a method for processing droplets in a microfluidic system. The method involves capturing a time sequence of images of a droplet as it moves through a channel. Each image is processed using a convolutional neural network to count the number of cells or other entities visible in the droplet. This information is then used to estimate the total number of cells or entities present, allowing for controlled microfluidic processes based on these estimates. The implementation of this method enhances monoclonality assurance through the use of machine learning techniques.

Another notable patent is related to "Droplet dispensing systems." This invention describes methods and systems for dispensing picolitre volume droplets containing one or more entities. The microfluidic droplet dispensing system includes a droplet feed line, a dispensing line, and a droplet outlet line. It features a first junction to manage the flow of droplets and dispensing fluid, along with a waste line to handle excess fluid. The system is designed to control the ejection of droplets effectively, ensuring precision in dispensing.

Career Highlights

David Holmes is currently associated with Sphere Fluidics Limited, where he continues to innovate in the field of microfluidics. His work has positioned him as a key figure in developing advanced technologies that enhance the capabilities of droplet-based systems.

Collaborations

He collaborates with notable colleagues such as Frank F Craig and Marian Rehak, contributing to a dynamic research environment that fosters innovation and development in microfluidic technologies.

Conclusion

David Holmes is a prominent inventor whose work in microfluidic systems has led to significant advancements in droplet processing and dispensing technologies. His contributions are paving the way for future innovations in the field.