David G Harrison

Title: The Innovations of David G Harrison

Introduction

David G Harrison is a notable inventor based in Atlanta, GA (US). He has made significant contributions to the field of biotechnology, particularly in the area of nitric oxide synthase research. His work has implications for both medical research and therapeutic applications.

Latest Patents

Harrison holds a patent for "Bovine endothelial nitric oxide synthase nucleic acids." This patent describes the cloning, nucleotide, and deduced amino acid sequences of the gene encoding endothelial nitric oxide synthase. The sequence includes binding domains for calcium/calmodulin, FMN, FAD, and NADPH. The enzyme has a molecular weight of 133,413 M.sub.r. The amino terminal portion of the enzyme exhibits a proline-rich region and several sites for proline-directed phosphorylation, as well as a potential substrate site for acyl transferase. DNA probes prepared from the nucleic acid sequence are useful in research and diagnostics to determine the level of nitric oxide synthase mRNA expressed by endothelial cells in both cell culture and intact tissues. These probes are also beneficial for detecting genetic abnormalities. The nitric oxide synthase gene can be transfected into blood vessels in vivo for enhanced synthesis of nitric oxide synthase, resulting in increased production of nitric oxide. Additionally, the gene can be transfected into host cells that do not normally express the enzyme for the production of endothelial nitric oxide synthase in large volumes. He has 1 patent to his name.

Career Highlights

Harrison is currently associated with Daiichi Pharmaceutical Co., Ltd., where he continues to advance his research in nitric oxide synthase. His work has garnered attention for its potential applications in various medical fields.

Collaborations

Throughout his career, Harrison has collaborated with notable colleagues, including R Wayne Alexander and Murphy T J. These collaborations have further enriched his research and contributed to the advancement of knowledge in his field.

Conclusion

David G Harrison's innovative work in the field of nitric oxide synthase research highlights his contributions to biotechnology. His patent and ongoing research efforts continue to pave the way for advancements in medical science.