David E Patterson

Title: Innovations of David E Patterson

Introduction

David E Patterson is a notable inventor based in St. Louis, MO (US). He has made significant contributions to the field of molecular chemistry, holding three patents that showcase his innovative approaches to visualizing and searching chemical compounds.

Latest Patents

One of Patterson's latest patents is titled "Visualizing high dimensional descriptors of molecular structures." This invention allows for the distribution of chemical compounds in high-dimensional molecular descriptor space to be viewed in two dimensions. By applying a projection method, this technique is particularly useful for analyzing large sets of compounds, such as those found in high-throughput screening (HTS) or virtual combinatorial libraries. The method involves selecting a representative subset of compounds and determining components from the high-dimensional descriptor space using Principal Component Analysis (PCA). The resulting two-dimensional projections provide clear insights into the distribution of chemical compounds.

Another significant patent is focused on "Creating and rapidly searching a virtual library of potential molecules using validated molecular structural descriptors." This invention addresses the challenge of selecting representative molecules from a vast chemically accessible universe. By validating molecular structural descriptors, Patterson's method enables the selection of optimally diverse subsets of molecules. Additionally, it allows for the identification of molecules with characteristics similar to a selected molecule. This innovation facilitates the generation of a vast virtual library of potential product molecules, enabling the search of billions of possible compounds in relatively short time frames.

Career Highlights

David E Patterson is currently associated with Tripos, Inc., where he continues to advance his research and innovations in molecular chemistry. His work has significantly impacted the field, particularly in the areas of molecular visualization and library creation.

Collaborations

Patterson has collaborated with notable colleagues, including Richard D Cramer and Robert D Clark. These collaborations have further enriched his research and contributed to the development of his innovative patents.

Conclusion

David E Patterson's contributions to molecular chemistry through his patents demonstrate his commitment to innovation and research. His work not only enhances the understanding of chemical compounds but also paves the way for future advancements in the field.