Location History:
- Macclesfield, EN (1977 - 1978)
- Macclesfield, GB (1978 - 1979)
Company Filing History:
Years Active: 1977-1979
Title: David C Aldridge: Innovator in Pharmaceutical Chemistry
Introduction
David C Aldridge is a notable inventor based in Macclesfield, GB. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of novel compounds with therapeutic applications. With a total of five patents to his name, Aldridge's work focuses on innovative fermentation processes and the synthesis of hydroxy acids.
Latest Patents
Aldridge's latest patents include a fermentation process for the production of (+)-2-(5.beta.-n-butyl-4.beta.-hydroxy-2-oxo-tetrahydrofuran-3.beta.-yl)-2.alpha.-methylacetic acid. This compound is recognized for its useful ulcer-healing properties. The process involves cultivating an organism known to produce dihydrocanadensolide, such as Penicillium canadense, under conventional conditions. The culture filtrate is then extracted at a pH range of 3.0-7.0 using a suitable solvent like ethyl acetate, followed by evaporation to dryness. In a preferred embodiment, the extraction occurs at a pH of 4.0-4.5. Another significant patent concerns novel racemic and optically active mono- and di-hydroxy alkanoic acids bearing phenyl and/or alkyl substituents. These compounds are intended for therapeutic use in treating duodenal or gastric ulcers.
Career Highlights
David C Aldridge has had a distinguished career at Imperial Chemical Industries Limited, where he has been instrumental in advancing pharmaceutical research. His innovative approaches have led to the development of compounds that hold promise for improving patient outcomes in ulcer treatment.
Collaborations
Aldridge has collaborated with notable colleagues, including Graham C Crawley and Colin J Strawson. These partnerships have fostered a collaborative environment that enhances the research and development of new pharmaceutical solutions.
Conclusion
David C Aldridge's contributions to pharmaceutical chemistry through his innovative patents and collaborative efforts highlight his role as a key inventor in the field. His work continues to pave the way for advancements in therapeutic applications.