Company Filing History:
Years Active: 1993-1999
Title: Innovations in Protein Production: The Contributions of David B Wilson
Introduction
David B Wilson is a prominent inventor based in Ithaca, NY (US), known for his significant contributions to the field of biotechnology. With a total of 5 patents, Wilson has focused on developing innovative systems for the production of proteins from recombinant DNA. His work has the potential to revolutionize how proteins are produced, making the process more efficient and cost-effective.
Latest Patents
One of Wilson's latest patents involves a system useful for the production of proteins from recombinant DNA in a single-celled organism. This invention provides a vector and method for the continuous production of excreted proteins without substantial host cell replication and without the need for antibiotics to control cell replication. The vector features an inducible promoter that activates a gene for protein production under conditions that inhibit host cell replication. Additionally, it includes a hybrid gene with a signal sequence fused to the gene for the protein to be produced. This innovative approach allows for the growth of large quantities of transformed single-celled organisms in the absence of inducing conditions, thereby reducing the risk of plasmid loss. The protein is produced under conditions that inhibit host cell replication, facilitating the immobilization of the single-celled organism on a solid support surface. This method can utilize encapsulated gram-negative bacteria, which can excrete protein products into the media, avoiding complications associated with inclusion bodies or contaminants from cell lysis.
Career Highlights
David B Wilson has made significant strides in his career, particularly through his work at Cornell Research Foundation Inc. His innovative research has garnered attention in the scientific community, contributing to advancements in biotechnology and protein production.
Collaborations
Wilson has collaborated with notable colleagues, including Michael L Shuler and Guifang Lao. These partnerships have further enhanced his research and development efforts in the field.
Conclusion
David B Wilson's contributions to protein production through recombinant DNA technology highlight his role as an influential inventor in biotechnology. His innovative approaches continue to pave the way for advancements in the field, showcasing the importance of research and collaboration in driving scientific progress.