Company Filing History:
Years Active: 2015-2020
Title: The Innovative Contributions of David A. Ingram
Introduction
David A. Ingram is a prominent inventor based in Indianapolis, IN (US), known for his significant contributions to the field of endothelial progenitor cells. With a total of 4 patents to his name, Ingram's work has advanced our understanding of cellular biology and regenerative medicine.
Latest Patents
Ingram's latest patents focus on the isolation, expansion, and use of clonogenic endothelial progenitor cells. His research identified a hierarchy of endothelial colony-forming cells (EPCs) from mammalian cord blood, umbilical vein, and aorta. A newly isolated cell, named high proliferative potential-endothelial colony-forming cell (HPP-ECFC), was characterized through single-cell assays that tested the proliferative and clonogenic potential of endothelial cells derived from cord blood, HUVECs, and HAECs. Notably, EPCs were found to reside in vessel walls, and the use of a feeder layer of cells derived from HPP-ECFCs from human umbilical cord blood stimulated the growth and survival of repopulating hematopoietic stem and progenitor cells. This stimulation was evidenced by increased numbers of progenitor cells in in vitro cultures and enhanced levels of human cell engraftment in the NOD/SCID immunodeficient mouse transplant system.
Career Highlights
Ingram's career is marked by his dedication to research and innovation in the field of cellular biology. His work has not only contributed to scientific knowledge but has also paved the way for potential therapeutic applications in regenerative medicine.
Collaborations
Throughout his career, Ingram has collaborated with notable colleagues, including Mervin C. Yoder and D. Wade Clapp. These collaborations have further enriched his research and expanded the impact of his findings.
Conclusion
David A. Ingram's innovative work in the field of endothelial progenitor cells has made significant strides in understanding cellular biology and its applications in medicine. His contributions continue to inspire future research and development in regenerative therapies.