This inventor holds 1 USPTO granted patent. Top assignee: Wisconsin Alumni Research Foundation. Active years: 1998.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1998
Title: David A Boothman: Innovator in Cancer Treatment
Introduction
David A Boothman is a prominent inventor based in Madison, WI (US). He is known for his significant contributions to cancer treatment through innovative chemical compounds. His work focuses on enhancing the efficacy of chemotherapy and radiotherapy while minimizing toxicity to normal cells.
Latest Patents
David A Boothman holds a patent for the synthesis and use of β-lapachone analogs. This patent, titled "3-Substituted-β-lapachone analogs and their use either alone or to augment chemotherapy or radiotherapy to induce programmed neoplastic cell death without exhibiting toxicity to surrounding normal cells," reveals the potential of these compounds in cancer therapy. Specifically, 3-allyl-β-lapachones, 3-alkyl-β-lapachones, and 3-halo-β-lapachones have been identified as Topoisomerase (Topo I) inhibitors. When used alone, these analogs can induce reversible single-strand breaks in the DNA of neoplastic cells, leading to apoptosis and cell death. However, when combined with chemotherapy or X-irradiation, they achieve irreversible Topo I-mediated breaks, enhancing their therapeutic effectiveness. The patent also discloses a new and more efficient chemical synthesis of these compounds.
Career Highlights
David A Boothman is affiliated with the Wisconsin Alumni Research Foundation, where he continues to advance research in cancer treatment. His innovative approach to drug development has garnered attention in the scientific community, contributing to the ongoing fight against cancer.
Collaborations
David has collaborated with notable colleagues, including Benjamin J Frydman and Donald T Witiak. Their combined expertise has furthered research efforts in the field of oncology.
Conclusion
David A Boothman's work exemplifies the intersection of innovation and healthcare, particularly in the realm of cancer treatment. His patented compounds represent a promising advancement in therapeutic strategies, aiming to improve patient outcomes while reducing side effects.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile