This inventor holds 6 USPTO granted patents and 4 published patent applications and 1 EPO patent. Top assignees: University of Michigan, University of Pittsburgh, Other. Active years: 2009-2019.
Location History:
- Verona, AZ (US) (2009)
- Verona, PA (US) (2010 - 2012)
- Pittsburgh, PA (US) (2011 - 2019)
Company Filing History:
3 out of 3,519 
3 out of 1,957 
3 out of 834,350 Years Active: 2009-2019
Title: Innovations and Contributions of Inventor Darren Wolfe
Introduction
Darren Wolfe is a notable inventor based in Pittsburgh, PA (US), recognized for his significant contributions to the field of gene delivery and pain therapy. With a total of 6 patents, his work has advanced the understanding and application of herpes simplex virus vectors and peptide biosynthesis.
Latest Patents
Darren Wolfe's latest patents include innovative technologies such as non-toxic HSV vectors for efficient gene delivery applications. This invention provides a herpes simplex virus (HSV) vector that does not express toxic HSV genes in non-complementing cells. The vector comprises a genome with one or more transgenes, capable of expressing a transgene for at least 28 days in non-complementing cells. The disclosed vectors include those with deletions in specific genes or alternative inactivating mutations. Additionally, the invention relates to viral stocks of these vectors, therapeutic compositions, and related methods.
Another significant patent focuses on peptide biosynthesis and pain therapy. This invention provides an expression cassette that includes a DNA sequence encoding amino acids 1-99 of human preproenkephalin, along with a precursor of a carboxy-amidated peptide. The invention also outlines a method for treating neuropathic pain by administering a gene transfer vector containing this expression cassette to patients. Furthermore, it describes a method for detecting peptides with desired effects through the introduction of a library of DNA sequences into host cells.
Career Highlights
Darren Wolfe has worked with esteemed institutions, including the University of Pittsburgh, where he has contributed to groundbreaking research and development in his field. His work has not only advanced scientific knowledge but has also paved the way for potential therapeutic applications.
Collaborations
Darren has collaborated with notable individuals such as Joseph C Glorioso, III and Joseph C Glorioso, enhancing the impact of his research through teamwork and shared expertise.
Conclusion
Darren Wolfe's innovative patents and contributions to gene delivery and pain therapy exemplify his dedication to advancing medical science. His work continues to inspire future research and development in these critical areas.