Company Filing History:
Years Active: 1999
Title: Innovations of Darko Brankovic in Antiviral Research
Introduction
Darko Brankovic is a notable inventor based in Bolingbrook, IL (US), recognized for his contributions to the field of antiviral research. He holds a total of four patents, showcasing his innovative approaches to developing potent HIV reverse transcriptase inhibitors. His work has significant implications for the treatment of HIV, a global health challenge.
Latest Patents
One of Brankovic's latest patents is titled "Method for the preparation of (+)-calanolide A and analogues thereof." This patent details a method for preparing (+)-calanolide A, a potent HIV reverse transcriptase inhibitor, from chromene 4. The disclosed method involves subjecting the chromene 4 intermediate to a chlorotitanium-mediated aldol reaction with acetaldehyde, which selectively produces (.+-.)-8a. The subsequent separation and enzyme-mediated resolution of (.+-.)-8a yield (+)-8a. The cyclization of (+)-8a under neutral Mitsunobu conditions, followed by Luche reduction of (+)-7, results in the production of (+)-calanolide A in high yield and enantiomeric purity. This method has also been extended to produce potent antiviral calanolide A analogues.
Career Highlights
Brankovic is currently employed at Sarawak Medichem Pharmaceuticals, Inc., where he continues to advance his research in pharmaceuticals. His innovative methods and dedication to antiviral research have positioned him as a key figure in the development of new therapeutic agents.
Collaborations
Throughout his career, Brankovic has collaborated with esteemed colleagues, including Michael T Flavin and Ze-Qi Xu. These collaborations have further enriched his research and contributed to the advancement of antiviral therapies.
Conclusion
Darko Brankovic's work in the field of antiviral research, particularly through his innovative methods for preparing HIV inhibitors, highlights his significant contributions to medical science. His patents reflect a commitment to addressing critical health challenges through innovation.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.