Darin Y Furgeson

Title: The Innovations of Darin Y Furgeson

Introduction

Darin Y Furgeson is a notable inventor based in Salt Lake City, UT (US). He has made significant contributions to the field of gene delivery through his innovative work with linear polyethylenimine-sterol conjugates. With a total of three patents to his name, Furgeson's research has advanced the methods of delivering nucleic acids into cells effectively.

Latest Patents

Furgeson's latest patents focus on the modification of linear polyethylenimine with sterols, such as cholesterol, in various geometries. These include linear shaped (L), T-shaped (T), and a combined linear- and T-shaped (LT) configuration. The resulting linear polyethylenimine-sterol conjugates are mixed with nucleic acids to form complexes that facilitate the delivery of these nucleic acids into mammalian cells. The results have shown that cells transfected with these complexes exhibit higher protein expression levels compared to those treated with linear polyethylenimine alone, and even double the expression of branched polyethylenimine, all while maintaining cell viability.

Career Highlights

Furgeson has worked with reputable organizations, including the University of Utah Research Foundation and Expression Genetics, Inc. His work has been pivotal in enhancing the efficiency of gene delivery systems, which has implications for various therapeutic applications.

Collaborations

Throughout his career, Furgeson has collaborated with esteemed colleagues such as Sung Wan Kim and Ram I Mahato. These partnerships have contributed to the advancement of his research and the development of innovative solutions in gene therapy.

Conclusion

Darin Y Furgeson is a distinguished inventor whose work in gene delivery has made a significant impact in the field. His innovative approaches and collaborations continue to pave the way for advancements in therapeutic applications.