Company Filing History:
2 out of 44 
1 out of 10 Years Active: 2001-2008
Title: The Innovative Contributions of Danny Huylebroeck
Introduction
Danny Huylebroeck is a notable inventor based in Liedekerke, Belgium. He has made significant contributions to the field of biotechnology, particularly in the area of transcription factors and their interactions. With a total of 3 patents to his name, Huylebroeck's work has implications for cancer research and therapeutic development.
Latest Patents
One of Huylebroeck's latest patents focuses on the identification of transcription factors through a method that utilizes nucleic acid sequences as bait. This innovative approach allows for the screening of libraries encoding potential transcription factors, leading to the isolation of specific factors that can influence tumor metastasis. His work highlights the role of zinc finger transcription factors, particularly SIP1, which is known to induce tumor metastasis by downregulating E-cadherin expression.
Another significant patent involves SMAD-interacting proteins, which are identified through a two-hybrid screening assay. This invention details the characteristics of SIP1, a specific protein that interacts with SMAD proteins and plays a crucial role in transcription activation. The minimal amino acid sequence necessary for binding with SMAD has been identified, providing valuable insights into the molecular mechanisms of gene regulation.
Career Highlights
Throughout his career, Huylebroeck has worked with esteemed institutions such as the Flemish Interuniversity Institute for Biotechnology. His research has contributed to advancements in understanding the molecular interactions that govern cellular processes, particularly in the context of cancer biology.
Collaborations
Danny Huylebroeck has collaborated with notable colleagues, including Kristin Verschueren and Jacques Remacle. These partnerships have fostered a collaborative environment that enhances the research output and innovation in the field of biotechnology.
Conclusion
Danny Huylebroeck's innovative work in the field of biotechnology, particularly in the study of transcription factors and their interactions, has made a significant impact on cancer research. His contributions continue to pave the way for new therapeutic strategies and a deeper understanding of molecular biology.
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