Daniel Michael Mandell

Title: Innovations by Daniel Michael Mandell

Introduction

Daniel Michael Mandell is a notable inventor based in Toronto, Canada. He has made significant contributions to the field of medical imaging and gas concentration control, holding three patents to his name. His work focuses on enhancing the assessment of vascular responses and improving methods for maintaining target arterial blood gas concentrations.

Latest Patents

One of Mandell's latest patents is titled "Imaging abnormalities in vascular response." This innovation combines Z maps with a standardized stimulus, specifically targeting arterial partial pressures of carbon dioxide. The results have shown enhanced images for assessing pathological cerebrovascular reactivity (CVR). For instance, the Z-map assessment of patients with known steno-occlusive diseases in the cervico-cerebral vasculature has demonstrated improved resolution in identifying the presence, localization, and severity of pathological CVR. This method has proven useful in reducing variability in CVR image comparisons across different tests and subjects.

Another significant patent is the "Method and apparatus to attain and maintain target arterial blood gas concentrations using ramp sequences." This invention provides a method for controlling the end-tidal partial pressure of a specific gas in a subject's lungs. The process involves obtaining a series of logistically attainable values for the gas, determining the required amount of gas to be inspired, and controlling a gas delivery device to achieve the target concentrations for each breath.

Career Highlights

Mandell is currently associated with Thornhill Scientific Inc., where he continues to innovate in the medical field. His work has implications for both research and therapeutic applications, showcasing his commitment to advancing medical technology.

Collaborations

Throughout his career, Mandell has collaborated with notable colleagues, including Joseph A Fisher and Olivia Sobczyk. These partnerships have likely contributed to the success and development of his innovative projects.

Conclusion

Daniel Michael Mandell's contributions to medical imaging and gas concentration control highlight his role as a significant inventor in the field. His patents reflect a dedication to improving diagnostic and therapeutic methods, ultimately benefiting patient care.