This inventor holds 3 USPTO granted patents and 3 published patent applications and 1 EPO patent. Top assignee: University of Southern California. Active years: 2012-2016.
Company Filing History:
Years Active: 2012-2016
Title: **Daniel J Weisenberger: Innovator in DNA Methylation Analysis**
Introduction
Daniel J Weisenberger, an accomplished inventor based in Playa Del Rey, California, holds three patents that have significantly contributed to the field of DNA methylation analysis. His innovative approaches are transforming cancer diagnosis and prognosis through advanced methodologies, providing the scientific community with new tools for understanding genetic markers.
Latest Patents
Among his notable patents, Daniel's work on DNA methylation analysis through digital bisulfite genomic sequencing and digital MethyLight stands out. These patents introduce novel sensitive methylation assays designed to compartmentalize bisulfite-treated genomic DNA over multiple PCR reaction wells. This technique allows for the detection of methylated DNA molecules amidst a predominantly unmethylated background.
Additionally, his digital bisulfite genomic DNA sequencing methods promise high-resolution insights into DNA methylation without requiring subcloning. The innovative processes dilute background signals and PCR contaminants while maintaining a high ratio of primer to methylated template DNA. Daniel's methodologies are particularly effective when analyzing biological fluids, such as urine and blood (plasma or serum), for their applications in cancer diagnosis, prognosis, and surveillance.
He has also developed high-throughput methods for analyzing repetitive element DNA methylation, where sensitive real-time PCR-based reactions allow for detailed measurement of global genomic 5-methylcytosine content. This includes analyzing Alu and LINE-1 repetitive sequences, leading to substantial contributions in population-based studies and genetic research.
Career Highlights
Daniel has significantly impacted the research landscape by working at renowned institutions such as the University of Southern California and the USC Stevens Center for Innovation. His role at these institutions highlights his commitment to advancing research in clinical applications of molecular biology and genetics.
Collaborations
Throughout his career, Daniel has collaborated with esteemed colleagues, including Peter W Laird and Mihaela Campan. These collaborations have helped enhance the depth and applicability of his research, leading to the development of innovative techniques that benefit the medical community.
Conclusion
Daniel J Weisenberger's inventive contributions to DNA methylation analysis are shaping the future of cancer diagnostics and genetic research. His patents reflect a commitment to excellence and innovation, positioning him as a key figure in the landscape of molecular biology. As advancements continue, his work will undoubtedly play a crucial role in enhancing our understanding of genetic influences on health and disease.