Location History:
- Watertown, MA (US) (2015)
- Brookline, MA (US) (2017 - 2019)
Company Filing History:
Years Active: 2015-2019
Title: Innovations of Daniel J Dwyer
Introduction
Daniel J Dwyer is an accomplished inventor based in Brookline, MA (US). He has made significant contributions to the field of molecular biology, particularly in the regulation of gene expression. With a total of three patents to his name, Dwyer's work has the potential to impact various applications in genetic research and biotechnology.
Latest Patents
One of Dwyer's latest patents is focused on cis/trans riboregulators. This invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules. The technology allows for both repression and activation of translation of an open reading frame. Repression is achieved through a regulatory nucleic acid element known as cis-repressive RNA (crRNA) within the 5' untranslated region (5' UTR) of an mRNA molecule. The crRNA forms a hairpin structure that blocks access to the mRNA transcript by the ribosome, preventing translation. In prokaryotic cells, the hairpin sequesters the ribosome binding site, while in eukaryotic cells, it is positioned upstream of the start codon. A small RNA, referred to as trans-activating RNA (taRNA), interacts with the crRNA to alter the hairpin structure, allowing the ribosome to access the transcript and activate translation.
Career Highlights
Dwyer has dedicated his career to advancing the understanding of gene regulation. His innovative approaches have garnered attention in the scientific community, leading to valuable patents that enhance the tools available for genetic manipulation. His work is instrumental in paving the way for new therapeutic strategies and research methodologies.
Collaborations
Throughout his career, Dwyer has collaborated with notable scientists, including James Joseph Collins and Farren J Isaacs. These partnerships have fostered a collaborative environment that encourages the exchange of ideas and the advancement of scientific knowledge.
Conclusion
Daniel J Dwyer's contributions to the field of molecular biology through his innovative patents highlight his role as a leading inventor. His work on cis/trans riboregulators exemplifies the potential for advancements in gene expression regulation. Dwyer's ongoing research and collaborations continue to shape the future of biotechnology and genetic research.