Daniel E Croker

Title: The Innovations of Daniel E Croker

Introduction

Daniel E Croker is a notable inventor based in Kenmore, Australia. He is recognized for his significant contributions to the field of receptor biology, particularly in the discovery of selective ligands for the C5A receptor 2. His work has implications for understanding and modulating immune responses.

Latest Patents

Croker holds a patent for the "Discovery of the first selective C5A receptor 2 (C5L2/C5AR2) ligands." This patent describes a method of selectively modulating the activity of the C5a receptor 2 (C5aR2). The method involves exposing the receptor to a compound that selectively modulates C5aR2 compared to the C5a receptor 1 (C5aR1). Notably, the compounds used in this method include peptide P32 or P59. Additionally, the patent outlines methods for recruiting β-arrestin 2 in a cell, modulating C5a-induced ERK1/2 activation in a macrophage, and selectively inhibiting the release of IL-6 from a macrophage.

Career Highlights

Croker has worked with prestigious institutions such as the University of California and the Texas A&M University System. His research has contributed to advancements in immunology and receptor pharmacology.

Collaborations

Croker has collaborated with notable colleagues, including Dimitrios Monikis and Christodoulos A Floudas. Their joint efforts have furthered the understanding of receptor interactions and their biological significance.

Conclusion

Daniel E Croker's innovative work in receptor biology has led to important discoveries that enhance our understanding of immune modulation. His contributions continue to influence research in this vital area of science.