The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2019
Filed:
Oct. 17, 2016
The Regents of the University of California, Oakland, CA (US);
The Texas a & M University System, College Station, TX (US);
The University of Queensland, St. Lucia, AU;
University of Sheffield, Sheffield, GB;
Dimitrios Monikis, Riverside, CA (US);
Trent Woodruff, Carindale, AU;
Matthew A. Cooper, Chapel Hill, AU;
Daniel E. Croker, Kenmore, AU;
Peter N. Monk, Sheffield, GB;
The Regents of the University of California, Oakland, CA (US);
The Texas A & M University System, College Station, TX (US);
The University of Queensland, St. Lucia, AU;
The University of Sheffield, Sheffield, GB;
Abstract
A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1). In some cases, the compound is peptide P32 or P59. Methods of recruiting β-arrestin 2 in a cell, modulating C5a-induced ERK1/2 activation in a macrophage, selectively inhibiting the release of IL-6 from a macrophage, are also provided.