Daniel DeSantis

Title: Innovations by Daniel DeSantis in Autoimmune Disease Treatment

Introduction

Daniel DeSantis is an accomplished inventor based in Pittsburgh, PA, known for his significant contributions to the field of autoimmune disease treatment. With a total of three patents to his name, he has focused on developing innovative solutions that enhance the migration of multipotent stem cells to targeted anatomical sites.

Latest Patents

One of his latest patents is centered around the treatment of autoimmune diseases using chemokine-loaded alginate microparticles. This invention provides a method for inducing the migration of multipotent stem cells to the anatomical site of the microparticles. The invention demonstrates various release profiles that depend on the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and intraarticular injection of these microparticles are particularly useful in conditions such as osteoarthritis. Furthermore, targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites affected by autoimmune disease symptoms can be achieved through encapsulation within liposomes that have targeting ligands. This innovative approach allows for the creation of a chemokine gradient, prompting multipotent stem cells to migrate to the distant anatomical site where the liposomes are attached.

Another patent by DeSantis also focuses on osteoarthritis treatment using chemokine-loaded alginate microparticles. Similar to his previous invention, this patent emphasizes the importance of microparticles in inducing stem cell migration and highlights the potential for local administration and targeted delivery.

Career Highlights

Throughout his career, Daniel DeSantis has worked with notable institutions, including the University of Pittsburgh and Ri.med Foundation. His work has significantly advanced the understanding and treatment of autoimmune diseases, showcasing his dedication to medical innovation.

Collaborations

Some of his notable coworkers include Steven R. Little and Riccardo Lucca Gottardi, who have contributed to his research and development efforts.

Conclusion

Daniel DeSantis is a pioneering inventor whose work in autoimmune disease treatment has the potential to transform patient care. His innovative approaches using chemokine-loaded alginate microparticles demonstrate a commitment to advancing medical science and improving health outcomes.