Dana Chreng

Title: Dana Chreng: Innovator in Oligomeric Compound Synthesis

Introduction

Dana Chreng is a prominent inventor based in San Marcos, CA (US). She has made significant contributions to the field of chemistry, particularly in the synthesis of oligomeric compounds. With a total of 3 patents to her name, Dana has developed innovative methods that enhance the efficiency and purity of chemical processes.

Latest Patents

Dana's latest patents include a method for solution phase detritylation of oligomeric compounds. This method allows for the removal of the 5'-terminal trityl group at reduced temperatures and lower pH levels compared to standard methods. The advantages of this approach include a reduced percentage of depurination and increased purity of the detritylated oligomeric compounds. Additionally, the method provides an increased rate of detritylation, making it a valuable advancement in the field.

Another notable patent by Dana focuses on the removal of monomethoxytrityl groups from oligomeric compounds. This method is performed at elevated temperatures and higher pH levels, differing from traditional techniques. The benefits of this innovation include a reduced percentage of depurination and improved yield of the final product.

Career Highlights

Dana currently works at Ionis Pharmaceuticals, Inc., where she continues to push the boundaries of chemical synthesis. Her work has been instrumental in developing new methodologies that enhance the quality and efficiency of pharmaceutical compounds.

Collaborations

Dana collaborates with her coworker, Michael T. Migawa, to further advance their research and development efforts. Together, they contribute to the innovative environment at Ionis Pharmaceuticals, Inc.

Conclusion

Dana Chreng is a trailblazer in the field of oligomeric compound synthesis, with her patents reflecting her commitment to innovation and excellence. Her contributions are paving the way for advancements in chemical processes that benefit the pharmaceutical industry.