Company Filing History:
Years Active: 2006-2014
Title: The Innovative Contributions of Dan Joseph Smith
Introduction
Dan Joseph Smith is a notable inventor based in San Diego, California. He has made significant contributions to the field of immunotherapy and drug delivery systems. With a total of two patents to his name, Smith's work focuses on enhancing the efficacy of therapeutic agents.
Latest Patents
Smith's latest patents include groundbreaking methods and compositions aimed at improving T cell responses. One patent details methods and compositions to generate and control the effector profile of T cells by simultaneous loading and activation of selected subsets of antigen presenting cells. This invention is directed towards novel compositions that effectively redirect class I-immunity to Tc1 effectors. It utilizes the unexpected loading of MHC I by peptide within an IgG backbone, combined with appropriate instruction of antigen presenting cells. Such compositions can transform seemingly ineffective therapeutics into highly effective ones, generating class I-restricted cytolytic cells and T cells that produce IFN-γ and IL-2, which are crucial for protection against virulent microbes and recovery from malignant tumors.
Another patent focuses on methods and compositions for delivering macromolecules to or via the respiratory tract. This invention provides methods that enhance the local and systemic bioavailability of macromolecules. The methods utilize lipid-based microstructures formed in combination with bioactive macromolecules, which exhibit a superior ability to rapidly release these macromolecules. This improved bioavailability is believed to result from reduced scavenging by bronchoalveolar macrophages and mucociliary clearance.
Career Highlights
Throughout his career, Dan Joseph Smith has worked with prominent companies in the biotechnology sector, including Nektar Therapeutics and Multicell Immunotherapeutics, Inc. His experience in these organizations has contributed to his expertise in immunotherapy and drug delivery systems.
Collaborations
Smith has collaborated with notable professionals in his field, including Luis A Dellamary and Adrian I Bot. These collaborations have likely enriched his research and development efforts.
Conclusion
Dan Joseph Smith's innovative patents and career achievements highlight his significant contributions to the fields of immunotherapy and drug delivery. His work continues to pave the way for advancements in therapeutic efficacy and patient care.