Dan I Piraner

Title: Dan I Piraner: Innovator in T-Cell Immunotherapy

Introduction

Dan I Piraner is a prominent inventor based in San Francisco, CA. He has made significant contributions to the field of immunotherapy, particularly in the regulation of T-cells. With a total of 4 patents, his work focuses on innovative methods to enhance the effectiveness of T-cell therapies.

Latest Patents

One of Dan's latest patents is titled "Thermal control of T-cell immunotherapy through molecular and physical actuation." This patent discloses methods, compositions, and kits that are suitable for spatiotemporal regulation of therapeutic T-cells. The invention includes thermal bioswitches that enable T-cells to sense small temperature changes, which serve as inputs for the actuation of genetic circuits. Additionally, the patent describes T-cell activity sensors and genetic circuits capable of inducing expression of a payload upon thermal stimulation or immune cell stimulation. The invention also covers thermally actuated immune cells and methods to prevent T-cell exhaustion, along with modular dimerization thermoswitches and related constructs.

Career Highlights

Dan I Piraner is affiliated with the California Institute of Technology, where he continues to advance research in immunotherapy. His innovative approaches have garnered attention in the scientific community, contributing to the development of more effective cancer treatments.

Collaborations

Dan has collaborated with notable researchers, including Mikhail G Shapiro and Mohamad H Abedi. These collaborations have further enriched his research and expanded the impact of his inventions.

Conclusion

Dan I Piraner is a key figure in the field of T-cell immunotherapy, with a focus on thermal control mechanisms that enhance therapeutic efficacy. His contributions are paving the way for future advancements in cancer treatment.