Location History:
- Alameda, CA (US) (2019)
- Oakland, CA (US) (2019 - 2020)
Company Filing History:
Years Active: 2019-2020
Title: The Innovations of Dan Groff
Introduction
Dan Groff is an accomplished inventor based in Oakland, CA. He has made significant contributions to the field of biotechnology, particularly in the area of protein expression. With a total of 3 patents to his name, Groff's work has the potential to impact various applications in medicine and research.
Latest Patents
One of Groff's latest patents focuses on the expression of biologically active proteins in a bacterial cell-free synthesis system. This invention describes methods and systems for improving the expression of properly folded, biologically active proteins of interest. The methods utilize a bacterial cell-free extract with an active oxidative phosphorylation system, incorporating an exogenous protein chaperone. The combination of a protein disulfide isomerase and a peptidyl-prolyl cis-trans isomerase has been found to produce a synergistic increase in the amount of properly folded proteins.
Another notable patent involves high growth capacity strains of auxotrophic bacteria and methods for generating them. This invention provides strains that express a complementing auxotrophic plasmid, allowing growth in the absence of specific amino acids. Additionally, it includes a method for preparing a bacterial cell extract from these high growth capacity strains for use in in vitro protein expression.
Career Highlights
Dan Groff is currently employed at Sutro Biopharma, Inc., where he continues to innovate in the field of protein synthesis. His work has garnered attention for its potential applications in therapeutic development and biomanufacturing.
Collaborations
Groff collaborates with talented individuals such as Patrick Rivers and Alice Yam, contributing to a dynamic research environment that fosters innovation and discovery.
Conclusion
Dan Groff's contributions to biotechnology through his patents and work at Sutro Biopharma, Inc. highlight his role as a significant inventor in the field. His innovative approaches to protein expression are paving the way for advancements in various scientific applications.