Dale E Herbranson

Title: The Innovations of Dale E. Herbranson

Introduction

Dale E. Herbranson is a notable inventor based in Lindenhurst, IL (US). She has made significant contributions to the field of pharmaceuticals, particularly in the development of stable compositions for medications. Her work is particularly relevant for the treatment and management of epilepsy and other convulsive states.

Latest Patents

Dale E. Herbranson holds a patent for a stable pharmaceutical composition of 3-(hydroxymethyl-5,5-diphenylhydantoin disodium phosphate ester). This prodrug of 5,5-diphenylhydantoin, commonly known as phenytoin, is widely used in medical treatments. The patent describes how the degradation of the prodrug to phenytoin can be controlled by adjusting the pH of the composition. Maintaining a pH between 8.3 to 9.4 allows for the production of diphenylglycinamide as the primary degradant, minimizing degradation to phenytoin. Deviating from this pH range can lead to unexpected product failure.

Career Highlights

Dale E. Herbranson is associated with E.I. DuPont de Nemours and Company, where she has been able to apply her innovative ideas in a corporate setting. Her work has contributed to advancements in pharmaceutical formulations, enhancing the efficacy and stability of important medications.

Collaborations

Throughout her career, Dale has collaborated with esteemed colleagues such as Earl R. Speicher and Leonard S. Rosenberg. These collaborations have fostered an environment of innovation and have led to significant advancements in their respective fields.

Conclusion

Dale E. Herbranson's contributions to pharmaceutical innovations highlight her expertise and dedication to improving medical treatments. Her patent work demonstrates the importance of stability in drug formulations, which is crucial for patient care.