Dae-Sik Lim

Title: Dae-Sik Lim: Innovator in ATM Kinase Modulation

Introduction

Dae-Sik Lim is a notable inventor based in Cordova, TN (US). He has made significant contributions to the field of biotechnology, particularly in the modulation of ATM kinase. With a total of 2 patents, his work has implications for screening and therapeutic applications.

Latest Patents

One of Dae-Sik Lim's latest patents focuses on ATM kinase modulation for screening and therapies. This invention relates to the identification of the consensus sequence phosphorylated by ATM kinase. This discovery has allowed for the identification of ATM kinase target proteins and the development of a convenient assay system for ATM kinase phosphorylation using fusion polypeptides as substrates. The assay system is adaptable for screening ATM modulators, particularly inhibitors. In a specific embodiment, the substrate recognition sequence and mutagenized variants of this sequence were incorporated into a GST fusion protein and assayed for phosphorylation by ATM kinase. This assay system is particularly useful in screening for ATM inhibitors, with validation performed using an ATM-kinase dead dominant-negative mutant.

Career Highlights

Dae-Sik Lim has established himself as a key figure in his field through his innovative research and patent contributions. His work has advanced the understanding of ATM kinase and its potential therapeutic applications.

Collaborations

Dae-Sik Lim has collaborated with notable colleagues, including Michael B. Kastan and Christine Canman. These collaborations have further enriched his research and contributions to the field.

Conclusion

Dae-Sik Lim's work in ATM kinase modulation represents a significant advancement in biotechnology. His patents and collaborations highlight his commitment to innovation and the potential for therapeutic applications in this area.