Company Filing History:
1 out of 832,843 Years Active: 2023
Title: Innovations in Gene Editing by Dacheng Ma
Introduction
Dacheng Ma is a prominent inventor based in Beijing, China. He has made significant contributions to the field of gene editing, particularly through his innovative work with the CRISPR/Cas9 system. His research focuses on enhancing the precision and efficiency of gene editing technologies.
Latest Patents
Dacheng Ma holds a patent for the "Engineering of a minimal SaCas9 CRISPR/Cas system for gene editing and transcriptional regulation optimized by enhanced guide RNA." This invention offers programmable and precise regulation of Cas9 functions by utilizing a set of compact Cas9 derivatives. These derivatives are created by deleting conserved HNH and/or REC-C domains based on structural information across variant class 2 CRISPR effectors. The patent also claims a novel strategy for engineering the dimeric gRNA-guided nuclease by splitting the mini-dSaCas9 and fusing the FokI domain right after the split point. This approach aims to increase on-target DNA cleavage efficiency while potentially reducing off-target effects due to the closer proximity of the dimeric Fold nuclease to the target sequence. By combining the optimized and compact gRNA expression cassette with the downsized SaCas9 derivatives, the entire CRISPR/Cas system can be loaded into a single AAV virus. This all-in-one AAV-CRISPR/Cas9 system is particularly appealing for biomedical applications that require safe and efficient in vivo delivery.
Career Highlights
Dacheng Ma's career is marked by his dedication to advancing gene editing technologies. His innovative approaches have positioned him as a key figure in the field, contributing to the development of safer and more effective gene editing tools.
Collaborations
Dacheng Ma has collaborated with Zhen Xie, further enhancing the impact of his research in the field of gene editing.
Conclusion
Dacheng Ma's work in engineering CRISPR/Cas9 systems represents a significant advancement in gene editing technology. His innovative approaches promise to enhance the safety and efficiency of gene editing applications in biomedical research.