D Mark Gleave

Title: Innovations by D Mark Gleave

Introduction

D Mark Gleave is an accomplished inventor based in Seattle, WA. He has made significant contributions to the field of medicinal chemistry, particularly in the development of non-steroidal compounds for steroid receptors. His work has implications for the diagnosis and treatment of various cancers.

Latest Patents

D Mark Gleave holds a patent for "Non-steroidal compounds for steroid receptors and uses relating thereto." This patent describes steroid receptor analogs that possess good binding affinity for steroid receptors. The analogs are designed with all carbon backbones, closely approximating the geometries of natural steroids, which is crucial for effective binding to receptor sites. Additionally, the analogs incorporate metal species binding arms that do not disrupt their receptor binding efficacy. These metal species binding arms can be tailored to chelate radionuclides, making them useful in diagnostic or therapeutic applications, such as binding androgen receptor sites for prostate cancer or estrogen receptor sites for breast and ovarian cancers.

Career Highlights

D Mark Gleave is currently associated with Neorx Corporation, where he continues to innovate in the field of cancer treatment. His work at Neorx Corporation has allowed him to collaborate with other experts in the field, enhancing the potential impact of his inventions.

Collaborations

D Mark Gleave has worked alongside Sudhakar Kasina, contributing to advancements in their shared field of research.

Conclusion

D Mark Gleave's innovative work in developing non-steroidal compounds for steroid receptors showcases his commitment to advancing medical science. His contributions have the potential to significantly impact cancer diagnosis and treatment.