Location History:
- Le Kremlin-Bicêtre, FR (2020)
- Le Kremlin-Bicetre, FR (2020 - 2023)
Company Filing History:
3 out of 1,745 
3 out of 99 
2 out of 10 
Years Active: 2020-2023
Title: Cécile Denis: Innovator in Antibody Research
Introduction
Cécile Denis is a prominent inventor based in Le Kremlin-Bicetre, France. He has made significant contributions to the field of antibody research, particularly in the prevention and treatment of bleeding episodes. With a total of 4 patents to his name, Denis has established himself as a key figure in medical innovation.
Latest Patents
One of his latest patents focuses on antibodies for the prevention or treatment of bleeding episodes. This invention relates to an isolated monoclonal antibody that specifically binds to the D4 domain of von Willebrand factor (VWF). It competes for binding to the VWF D4 domain with ADAMTS13 and partially inhibits ADAMTS13-mediated degradation of VWF. The isolated monoclonal antibody comprises a heavy chain with a variable domain that includes at least one CDR with specific sequences, as well as a light chain with its own variable domain CDR sequences. These antibodies are particularly useful for preventing or treating bleeding episodes in patients with aortic stenosis or those with ventricular assist devices (VAD). Another significant patent involves methods of administering neutralizing anti-protease nexin-1 antibodies to treat hemophilia A, providing new avenues for addressing hemorrhagic diseases.
Career Highlights
Cécile Denis has worked with esteemed institutions such as the Institut National de la Santé et de la Recherche Médicale and Université Paris-Sud. His work has been instrumental in advancing the understanding and treatment of bleeding disorders through innovative antibody therapies.
Collaborations
Denis has collaborated with notable professionals in his field, including Petrus Lenting and Olivier Christophe. These partnerships have further enriched his research and contributed to the development of groundbreaking medical solutions.
Conclusion
Cécile Denis is a distinguished inventor whose work in antibody research has the potential to transform the treatment of bleeding disorders. His innovative patents and collaborations highlight his commitment to advancing medical science and improving patient outcomes.