Cynthia Hao

Title: Innovations by Cynthia Hao in RNA Sequencing

Introduction

Cynthia Hao is an accomplished inventor based in Saratoga, CA (US). She has made significant contributions to the field of molecular biology, particularly in the area of RNA sequencing. Her innovative work has the potential to advance our understanding of gene expression and its implications in various biological processes.

Latest Patents

Cynthia Hao holds a patent for her invention titled "In situ sequencing of RNA transcripts with non-uniform 5' ends." This patent describes methods for performing in situ sequencing of RNA transcripts that possess non-uniform 5' ends. The technique involves inducing the reverse transcription (RT) enzyme to 'template-switch' to a separate oligonucleotide, which serves as the template for the upstream flanking region. This method allows for the detection of RNA transcripts through padlock probe detection, rolling circle amplification, and fluorescent in situ sequencing. The applications of this method are vast, including the analysis of exogenously introduced transcripts, naturally occurring transcripts, and modified transcripts.

Career Highlights

Cynthia is currently employed at Insitro, Inc., where she continues to push the boundaries of RNA research. Her work is instrumental in developing innovative solutions that can be applied in various research and clinical settings.

Collaborations

Cynthia collaborates with talented individuals in her field, including Max R Salick and Ci Chu. These partnerships enhance her research and contribute to the advancement of RNA sequencing technologies.

Conclusion

Cynthia Hao's contributions to RNA sequencing represent a significant advancement in molecular biology. Her innovative methods have the potential to transform how researchers analyze gene expression and its implications in health and disease.