Company Filing History:
Years Active: 2001-2004
Title: Innovations in Molecular Constructs by Cynthia A. Richards
Introduction
Cynthia A. Richards is a prominent inventor based in Durham, NC (US), known for her significant contributions to the field of molecular biology. With a total of 5 patents, her work focuses on developing novel molecular chimaeras that have the potential to revolutionize cancer treatment.
Latest Patents
Her latest patents include groundbreaking innovations such as molecular constructs with a carcinoembryonic antigen (CEA) transcriptional regulatory sequence. These novel molecular chimaeras are produced using recombinant DNA techniques and comprise a target-tissue specific transcriptional regulatory sequence (TRS) that controls the expression of heterologous enzymes. For instance, the constructs can utilize Varicella Zoster Virus Thymidine Kinase (VZV TK) or non-mammalian Cytosine Deaminase (CD). The molecular chimaeras are packaged into synthetic retroviral particles capable of infecting mammalian tissue. Once administered to a host, the TRS is selectively transcriptionally activated in target tissues, such as cancerous cells. This activation allows for the administration of compounds that are selectively metabolized by the enzyme, producing cytotoxic or cytostatic metabolites in situ, thereby selectively killing or arresting the growth of target cells.
Career Highlights
Cynthia has worked with notable companies in the pharmaceutical industry, including Glaxo Wellcome Inc. and SmithKline Beecham Corporation. Her expertise in molecular biology and innovative approaches to cancer treatment have positioned her as a leader in her field.
Collaborations
Throughout her career, Cynthia has collaborated with esteemed colleagues, including Brian Huber and Michael Phillip Weiner, contributing to the advancement of molecular biology research.
Conclusion
Cynthia A. Richards continues to make significant strides in the field of molecular constructs, with her innovative patents paving the way for future advancements in cancer therapy. Her work exemplifies the impact of scientific innovation on healthcare and the potential for transformative treatments.
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