Corinne Abernathy

Title: Corinne Abernathy: Innovator in Viral Vector Production

Introduction

Corinne Abernathy is a notable inventor based in Gainesville, FL (US). He has made significant contributions to the field of viral vector production, particularly through his innovative work on temperature-sensitive adeno-associated virus (AAV) proteins.

Latest Patents

Corinne Abernathy holds 1 patent for his invention titled "Temperature-sensitive regulation of viral vector production." This invention provides temperature-sensitive (ts) AAV Rep78 and Rep68 proteins. In preferred embodiments, the ts AAV Rep78 and Rep68 proteins have missense mutations at amino acid positions 40, 42, and 44 that confer a temperature-sensitive phenotype. The invention also includes nucleotide sequences and vectors encoding the inventive ts Rep proteins. Additionally, a hybrid adenovirus vector is provided that stably comprises a nucleotide sequence encoding a ts AAV Rep protein according to the invention. The present invention also outlines methods of packaging AAV vectors and methods of ex vivo gene delivery using the ts Rep proteins. Furthermore, it provides cells containing the ts AAV Rep proteins, preferably stably integrated into the genome of the cell.

Career Highlights

Corinne Abernathy is affiliated with the University of North Carolina at Chapel Hill, where he continues to advance research in viral vector technology. His work has implications for gene therapy and other medical applications, showcasing his commitment to innovation in the field.

Collaborations

He has collaborated with notable colleagues, including Denise Gavin and Daniel Pereira, contributing to a dynamic research environment that fosters innovation and discovery.

Conclusion

Corinne Abernathy's contributions to the field of viral vector production highlight his role as an innovator and researcher. His work on temperature-sensitive AAV proteins is paving the way for advancements in gene therapy and related applications.