Company Filing History:
Years Active: 2025
Title: Constantinos Mikelis: Innovator in Breast Cancer Treatment
Introduction
Constantinos Mikelis is an accomplished inventor based in Amarillo, TX (US). He has made significant contributions to the field of cancer treatment, particularly focusing on innovative therapeutic methods for combating breast cancer. His work is characterized by a commitment to advancing medical science and improving patient outcomes.
Latest Patents
Mikelis holds a patent for "Substituted bisphenylalkylurea compounds and methods of treating breast cancer." This patent discloses a composition and method for a therapeutic treatment that effectively targets triple negative breast cancers (TNBCs). The class of urea compounds he developed acts by inhibiting the mTOR signaling pathway, a central regulator of mammalian metabolism and physiology. When this pathway is inhibited, it leads to the induction of autophagocytosis. Furthermore, the disclosed compounds are capable of reinitiating the p53 cycle and inhibiting the BNIP3/BNIP3L pathway. Notably, these compounds also demonstrate the ability to cross the blood-brain barrier, where metastases can form. This innovative drug has the potential to serve as a powerful new treatment for invasive TNBCs.
Career Highlights
Constantinos Mikelis is affiliated with the Texas Tech University System, where he continues to engage in groundbreaking research. His work has garnered attention for its potential impact on cancer therapies and has positioned him as a notable figure in the scientific community.
Collaborations
Mikelis collaborates with esteemed colleagues, including Nadezhda German and Ruwein Zhang. Their combined expertise contributes to the advancement of research in cancer treatment and enhances the potential for innovative solutions in the medical field.
Conclusion
Constantinos Mikelis is a pioneering inventor whose work in developing new treatments for breast cancer showcases his dedication to improving healthcare. His innovative approaches and collaborations highlight the importance of research in combating serious health challenges.