Company Filing History:
2 out of 23 
1 out of 1 
1 out of 10 Years Active: 1997-2003
Title: The Innovative Mind of Clyde Witham
Introduction
Clyde Witham, a talented inventor based in San Diego, CA, has made significant contributions to the field of medical technology with his groundbreaking patents. With a total of four patents to his name, Witham’s work focuses on the development of inhaled vaccines and dry powder inhalers, demonstrating his expertise in creating effective healthcare solutions.
Latest Patents
Clyde Witham's latest patents include a pioneering method for creating an immune response with inhaled vaccines. This innovative approach involves preparing a vaccine in the form of a dry powder, with powder particles ranging in aerodynamic particle size from 1 to 100 microns. The powder is loaded into a dry powder inhaler, allowing for inhalation at an inspiratory flow rate of less than 60 liters per minute. This method enables a mucosal immune response through the deposition of particles in the upper respiratory tract, while also creating a systemic immune response by delivering particles into the deep lung. Notably, the vaccine material retains its potency despite size reduction, achieved through techniques such as jet milling.
Additionally, Witham developed a sophisticated dry powder inhaler featuring a dispersion chamber filled with beads. During use, a dose of dry powder is released into the chamber, and as the patient inhales through a nosepiece or mouthpiece, air circulates within the chamber, causing the beads to roll and collide with drug particles. This process effectively separates the active drug particles from larger carrier particles, generating a fine powder aerosol for inhalation. The design focuses on enhancing airflow and powder dispersion while requiring minimal effort from the patient.
Career Highlights
Clyde Witham has played an essential role in advancing pharmaceutical technology through his work with reputable companies such as Dura Pharmaceuticals, Inc. and Dura Pharmaceuticals, ICN. His innovations have been pivotal in shaping modern inhalation therapy, benefiting patients requiring aerosolized medication.
Collaborations
Throughout his career, Witham has collaborated with notable professionals in the field, including Robert F. Eisele and Bernard Greenspan. These partnerships have fostered a collaborative environment that has propelled the development and refinement of their shared innovations.
Conclusion
Clyde Witham stands as a notable figure in the realm of medical inventions, particularly with his advancements in inhaled vaccine technology and dry powder inhalers. His dedication to enhancing patient treatment options reflects the impactful work of inventors in today’s healthcare landscape. With a commitment to innovation, Clyde Witham continues to influence the future of medicine through his inventive spirit and collaborative efforts.