Clyde H Barlow

Title: Clyde H Barlow: Innovator in Optical Detection Technology

Introduction

Clyde H Barlow is a notable inventor based in Olympia, WA (US). He has made significant contributions to the field of optical detection and imaging, particularly in biological research. With a total of 2 patents, Barlow's work focuses on advancing methods for analyzing circulatory flow in biological tissues.

Latest Patents

One of Barlow's latest patents is titled "Automated optical detection of tissue perfusion by microspheres." This innovative method and apparatus enable the optical detection and imaging of regional circulatory flow in biological tissues for research purposes. The process involves perfusing an animal or plant organ with a saline suspension of colored and/or fluorescent microspheres. After excising the organ, it is fixed into a specimen block suitable for mounting in a microtome or other apparatus.

Under the automatic control of a microcomputer equipped with a frame grabber, a surface layer of the block is removed. The newly exposed surface receives a flash of illumination from a light source. Light reflected by colored microspheres or emitted by fluorescent microspheres is then detected by a CCD video camera aimed at the block. The microcomputer also controls light filters with suitable light bandpasses, which are interposed between the light sources and the block, as well as between the block and the camera. The video signals are converted into position coordinates with associated optical intensities, allowing for the computation and display of regional circulatory flow on a monitor. This method allows for the segregation of microspheres into batches with different color permutations, facilitating extended sequences of interventions using a limited number of colors.

Career Highlights

Clyde H Barlow has established himself as a prominent figure in the field of optical detection technology. His innovative approaches have paved the way for advancements in biological research, particularly in understanding circulatory dynamics.

Collaborations

Barlow has collaborated with Jeffrey J Kelly, contributing to the development and refinement of his patented technologies. Their partnership has enhanced the effectiveness and applicability of Barlow's inventions in research settings.

Conclusion

Clyde H Barlow's contributions to optical detection technology exemplify the impact of innovation in biological research. His patents reflect a commitment to advancing scientific understanding through technological advancements.