Clive D Richardson

Title: Clive D Richardson: Innovator in Ceramide Preparation

Introduction

Clive D Richardson is a notable inventor based in Aylesford, GB. He has made significant contributions to the field of chemistry, particularly in the preparation of ceramides. His innovative approach has led to the development of a unique process that enhances the efficiency of ceramide production.

Latest Patents

Clive D Richardson holds a patent for a process for the preparation of ceramides. This invention involves a two-step process that converts a 2-hydroximino-3-oxo-alkanoate into a 2-alkanoylamido-3-oxo-alkanoate intermediate. The process includes acylation of the oxime and reduction of the oxime ester group to an amido group. Following this, the keto and ester groups of the intermediate are reduced to form the 1,3 diol of the ceramide. The oxime acylation and the first reduction can be performed consecutively or simultaneously. The first reduction is preferably a catalytic hydrogenation, while the second reduction is ideally a borohydride reduction. Additionally, the invention introduces novel 2-alkanoylamido-3-oxo-alkanoates and 2-alkanoyloximino-3-oxo-alkanoates, which serve as useful intermediates for ceramide conversion.

Career Highlights

Clive D Richardson is associated with Unilever Patent Holdings B.V., where he has been able to apply his expertise in the field of chemical innovations. His work has not only contributed to the company but has also advanced the understanding of ceramide production processes.

Collaborations

Throughout his career, Clive has collaborated with notable colleagues such as Paul Nicholas Davey and Brian J Hardinge. These collaborations have fostered a productive environment for innovation and development in their respective fields.

Conclusion

Clive D Richardson's contributions to the preparation of ceramides exemplify the impact of innovative thinking in chemistry. His patented process and collaborations highlight the importance of teamwork in advancing scientific knowledge.