Claudia Marcolli

Title: Innovations by Claudia Marcolli: Pioneering Advances in Sealing Systems and Polymorphic Forms

Introduction

Claudia Marcolli, an accomplished inventor based in Zurich, Switzerland, has made significant contributions to the fields of materials science and pharmaceutical formulations. With a remarkable portfolio of eight patents, she has developed innovative solutions that cater to a variety of scientific challenges. Her work focuses primarily on advancing sealing systems and creating novel polymorphic forms of compounds.

Latest Patents

Among her latest inventions, Claudia's patented sealing system with flow channels stands out. This innovative device comprises a support with at least two hermetically fitted seals arranged in a row. The design incorporates inlet and outlet openings, along with internal channels that enable efficient flow management. This system is particularly suitable for simultaneous studies, including those utilizing microtitration plates. By allowing for physical measurements directly in containers, her invention aims to facilitate screening processes essential for the discovery and development of polymorphic and pseudomorphoric forms, as well as optimal crystallization conditions.

Another significant innovation is related to the preparation of polymorphic forms of sertraline hydrochloride. Claudia's research reveals that polymorphic form II can be conveniently produced by adding hydrogen chloride to a solution of sertraline free amine in a ketone. The process involves seeding the solution with crystals of polymorphic form II and can be enhanced by heating before the hydrochloric acid addition.

Career Highlights

Claudia has held influential roles in reputable companies, including Ciba Specialty Chemicals Corporation and Solvias AG. Her tenure at these organizations has been marked by her commitment to research and development, driving advancements that have far-reaching implications in both industrial and pharmaceutical contexts.

Collaborations

Throughout her career, Claudia has collaborated with esteemed colleagues such as Martin Szelagiewicz and Paul Adriaan Van Der Schaaf. These partnerships have fostered a dynamic exchange of ideas and expertise, further enriching her contributions to the scientific community.

Conclusion

Claudia Marcolli embodies the spirit of innovation with her inventive solutions that address complex problems in sealing systems and pharmaceutical formulations. Her extensive body of work, underscored by a series of patents and collaborations, positions her as a leading figure in her field. As her inventions continue to shape the landscape of materials science and chemistry, Claudia remains a noteworthy source of inspiration for aspiring inventors and researchers.