Company Filing History:
Years Active: 1981-1983
Title: Claude H Moussebois: Innovator in Immunoassay Technology
Introduction
Claude H Moussebois is a notable inventor based in Brussels, Belgium. He has made significant contributions to the field of immunoassays, with a focus on improving the accuracy and reliability of diagnostic tests. His innovative approaches have led to the development of two patents that enhance the performance of immunoassays.
Latest Patents
Moussebois's latest patents include groundbreaking methods for conducting immunoassays using F(AB').sub.2 fragments. This technique allows for the detection of antigens or haptens without interference from endogenous rheumatoid factor (RF) and complement component Clq. By utilizing F(ab').sub.2 fragments instead of whole immunoglobulin antibodies, the need for pre-treatment of the fluid under assay is eliminated. The patents also describe a reagent comprising F(ab').sub.2 fragments that are insolubilized on a water-insoluble substrate, particularly a particulate substrate, which can be used in various types of assays, including latex agglutination and competitive binding assays.
Another patent focuses on the creation of insolubilized antibodies, F(ab').sub.2 fragments, and protein antigens. This is achieved by coupling these components to a water-insoluble substrate using a bridging agent that covalently binds to sulfur atoms in the antibody or protein, rather than to free amino groups. The use of a chloracetyl-terminated bridging agent is preferred, and the patent also introduces a novel class of bridging agents with anhydride and monochloracetyl end groups, which are useful for making these reagents.
Career Highlights
Claude H Moussebois has had a distinguished career, working with Technicon Instruments Corporation, where he has been able to apply his innovative ideas in a practical setting. His work has significantly advanced the field of immunoassays, making diagnostic testing more efficient and reliable.
Collaborations
Moussebois has collaborated with notable colleagues, including Joseph Limet and Cesar L Cambiaso. These partnerships have contributed to the development of his patents and the advancement of immunoassay technology.
Conclusion
Claude H Moussebois is a prominent inventor whose work in immunoassays has led to significant advancements in diagnostic testing. His innovative patents reflect his commitment to improving the accuracy