Clarke J Halfman

Title: Inventor Spotlight: Clarke J Halfman

Introduction

Clarke J Halfman is an innovative inventor based in Highland Park, IL. He has made significant contributions to the field of immunoassays and fluorescence assays, holding two patents that showcase his expertise and creativity in scientific research.

Latest Patents

Halfman's most recent patents revolve around advanced fluorescence ligand binding assays. The first patent describes a fluorescence ligand binding assay for a sample containing an unknown amount of ligand, involving direct intensity measurements. In this process, the sample is mixed with a dye-labeled analyte and a specific antibody. By incorporating a surfactant in sufficient amounts to form micelles, significant differences in fluorescent intensity are observed between the bound and unbound labeled analyte, provided that the surfactant ions and dye ions possess the same charge polarity while the analyte moiety carries an opposite charge polarity.

His second patent also focuses on a homogeneous fluorescence ligand binding assay, similarly employing direct intensity measurements. This methodology is applicable in immunoassays where fluorescein labeled analyte is introduced into the solution followed by the addition of a specific antibody. The addition of sodium dodecyl sulfate as a surfactant allows for distinct fluorescent intensity variations between the bound and unbound dyes, enabling accurate measurements and analyses.

Career Highlights

Clarke J Halfman is affiliated with the University of Health Sciences/The Chicago Medical School, where he has dedicated his career to advancing biomedical research. His work emphasizes the importance of innovative assay techniques that can lead to significant improvements in diagnostic methodologies.

Collaborations

Throughout his career, Halfman has engaged in collaborations with various researchers and institutions in the medical field. His patents reflect a commitment to enhancing the accuracy and efficacy of immunoassays, underscoring the collaborative nature of scientific innovation.

Conclusion

Clarke J Halfman’s contributions to the field of immunoassays through his patents represent a remarkable fusion of creativity and scientific rigor. His innovative approaches to fluorescence ligand binding assays hold promise for the future of diagnostics, benefiting both researchers and practitioners in the medical community.