Company Filing History:
Years Active: 2017
Title: Christopher Lengauer: Innovator in Cancer Research
Introduction
Christopher Lengauer is a prominent inventor based in Noisy-le-Roi, France. He has made significant contributions to the field of cancer research, particularly in understanding the genetic mutations that affect cellular growth and invasion. His work has implications for therapeutic interventions in colorectal cancers.
Latest Patents
Christopher Lengauer holds a patent related to the P13K pathway mutations in cancer. This patent highlights the important role of protein kinases in pathways affecting cellular growth and invasion. In his research, he analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. He identified mutations in eight genes, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway. The alterations in these genes occurred in different tumors and did not overlap with mutations in PIK3CA or other non-serine-threonine kinase members of the PI3K pathway. This suggests that mutations in any of these genes have equivalent tumorigenic effects. His findings demonstrate that the PI3K pathway is a major target for mutational activation in colorectal cancers and provide new opportunities for therapeutic intervention.
Career Highlights
Christopher Lengauer is affiliated with The Johns Hopkins University, where he continues to advance his research in cancer biology. His work has garnered attention for its innovative approach to understanding the genetic underpinnings of cancer.
Collaborations
He has collaborated with notable colleagues, including Donald William Parsons and Tian-li Wang, to further explore the complexities of cancer mutations and their implications for treatment.
Conclusion
Christopher Lengauer's contributions to cancer research through his patent on P13K pathway mutations exemplify the critical role of innovation in the fight against cancer. His work not only enhances our understanding of cancer biology but also opens new avenues for therapeutic strategies.