Company Filing History:
Years Active: 1999
Title: The Innovative Contributions of Christian Tho Slashedgersen
Introduction
Christian Tho Slashedgersen is a notable inventor based in Mundelstrup, Denmark. She has made significant contributions to the field of protein refolding, which is crucial for various biotechnological applications. Her innovative approach has led to the development of a novel method that enhances the efficiency of producing correctly folded proteins.
Latest Patents
Christian holds a patent for an "Iterative method of at least five cycles for the refolding of proteins." This method is designed to produce correctly folded proteins from a mixture of misfolded proteins, such as bacterial inclusion-body aggregates. A major aspect of her method is the achievement of overall efficiency through a time-sequence of multiple denaturation-renaturation cycles. This results in the gradual accumulation of correctly folded proteins. The method has proven effective for a variety of recombinant proteins. Additionally, her patent includes novel encrypted recognition sites for bovine coagulation factor X.sub.a, which can be activated in vitro by controlled oxidation or reversible derivatization of cysteine residues. This innovation generates new cleavage sites for factor X.sub.a, and she has also developed two new recombinant serine proteases that exhibit narrow substrate specificity for these recognition sites.
Career Highlights
Christian is currently associated with Denzyme Aps, where she continues to advance her research in protein refolding and related biotechnological innovations. Her work has garnered attention for its potential applications in therapeutic protein production and other biopharmaceuticals.
Collaborations
Christian collaborates with notable colleagues, including Thor Las Holtet and Michael Etzerodt. Their combined expertise contributes to the innovative research environment at Denzyme Aps.
Conclusion
Christian Tho Slashedgersen's contributions to the field of protein refolding exemplify the impact of innovative thinking in biotechnology. Her patented methods and ongoing research continue to pave the way for advancements in the production of therapeutic proteins.