Company Filing History:
Years Active: 2001-2005
Title: Chris Pinko: Innovator in Protein Engineering
Introduction
Chris Pinko is a notable inventor based in San Diego, CA. He has made significant contributions to the field of protein engineering, particularly in the study of vascular endothelial growth factor receptor-2 (VEGFR2/KDR). With a total of 5 patents to his name, Pinko's work has implications for therapeutic advancements in various disease conditions.
Latest Patents
One of Chris Pinko's latest patents involves the modifications of the VEGF receptor-2 protein and methods of use. This patent details a 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of VEGFR2/KDR, which is a key enzyme in angiogenesis. The protein construct features a modified catalytic linker and demonstrates comparable in vitro kinase activity to constructs containing the entire KID. Importantly, this construct allows for complete crystallization of the protein, enabling characterization through X-ray crystallography. The invention also discloses the use of the X-ray crystallographic data for identifying and constructing potential therapeutic compounds for treating various diseases.
Career Highlights
Chris Pinko is currently employed at Agouron Pharmaceuticals, Inc., where he continues to advance his research in protein engineering. His work has been pivotal in understanding the mechanisms of angiogenesis and developing therapeutic strategies.
Collaborations
Throughout his career, Pinko has collaborated with esteemed colleagues, including Michele Ann McTigue and Camran V Parast. These collaborations have enriched his research and contributed to the success of his innovative projects.
Conclusion
Chris Pinko's contributions to protein engineering and his innovative patents highlight his role as a leading inventor in the field. His work not only advances scientific understanding but also paves the way for potential therapeutic applications.