Ching-Yun Lee

Title: Innovations of Ching-Yun Lee in Nuclear Medicine

Introduction

Ching-Yun Lee is a notable inventor based in Taoyuan County, Taiwan. He has made significant contributions to the field of nuclear medicine through his innovative inventions. With a total of 3 patents, his work focuses on enhancing medical imaging and treatment methodologies.

Latest Patents

One of his latest patents is titled "Method for preparing S-Bz-MAG3 as a precursor of contrast media." This invention provides a streamlined method for synthesizing S-Bz-MAG3, which serves as a bifunctional chelator. The process involves thioglycolic acid and benzoyl chloride for thiol protection, followed by the conversion of N,N'-dicyclohexylcarbodiimide and N-hydroxysuccinimide into ester compounds. These compounds then react with triglycine through an amide bonding reaction, resulting in a product that is recrystallized and purified for use in nuclear medicine imaging and tumor radiotherapy. This method reduces the complexity of synthesis and enhances productivity.

Another significant patent is the "Benzodiazepine derivative and method of producing the same." In this invention, isatoic anhydride or 5-chloroisatoic anhydride is reacted with amino acid ester hydrochloride to achieve a simple cyclization. This process yields a product with minimal by-products, eliminating the need for complicated separation and purification methods. The resulting benzodiazepine derivative exhibits improved lipo-solubility and chlorine ion permeability, making it effective for various pharmacological applications, including as a contrast agent.

Career Highlights

Ching-Yun Lee has worked with esteemed organizations such as the Atomic Energy Council and the Institute of Nuclear Energy Research. His experience in these institutions has allowed him to contribute significantly to advancements in nuclear medicine.

Collaborations

Throughout his career, Ching-Yun Lee has collaborated with notable colleagues, including Yu Lung Chang and Cheng-Fang Hsu. These partnerships have fostered innovation and development in his field.

Conclusion

Ching-Yun Lee's contributions to nuclear medicine through his patents and collaborations highlight his role as an influential inventor. His innovative methods are paving the way for advancements in medical imaging and treatment.