Ching-Wei Liu

Title: Innovations of Ching-Wei Liu in Pharmaceutical Chemistry

Introduction

Ching-Wei Liu is a notable inventor based in Taipei, Taiwan. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the preparation of fluconazole, a crucial antifungal medication. His innovative approach has led to the development of a patented process that enhances the efficiency of fluconazole production.

Latest Patents

Ching-Wei Liu holds a patent for the "Preparation of fluconazole and pharmaceutically acceptable salts thereof." This patent outlines a detailed process that includes several key steps: first, acylating 1,3-difluorobenzene (DFB) to obtain 2-chloro-2',4'-difluoroacetophenone (CAP); second, alkylating 4-amino-4H-1,2,4-triazole (4-AT) with CAP to produce 2-(1H-1,2,4-triazol-1-yl)-2',4'-difluoroacetophenone (TAAP) salt; third, deaminating TAAP salt to yield TAAP; and finally, reacting TAAP with 1,2,4-triazole to obtain fluconazole. This innovative process has the potential to streamline the production of this important pharmaceutical compound.

Career Highlights

Ching-Wei Liu is associated with the Development Center for Biotechnology, where he has been instrumental in advancing research and development in biotechnology and pharmaceuticals. His work has not only contributed to the scientific community but has also had a significant impact on public health through the development of effective treatments.

Collaborations

Ching-Wei Liu collaborates with esteemed colleagues, including Kae-Shyang Shih and Lie-Rong Chen. These partnerships enhance the research environment and foster innovation within the Development Center for Biotechnology.

Conclusion

Ching-Wei Liu's contributions to pharmaceutical chemistry, particularly through his patented process for fluconazole preparation, exemplify the importance of innovation in the field. His work continues to influence the development of effective medical treatments, showcasing the vital role of inventors in advancing healthcare solutions.