Company Filing History:
4 out of 40 
2 out of 4 Years Active: 1993-2000
Title: Innovations and Contributions of Inventor Ching-Shih Chen
Introduction
Ching-Shih Chen is a notable inventor based in Wakefield, Rhode Island, who has made significant contributions to the field of biochemistry and pharmaceuticals. With a total of six patents to his name, Chen's work focuses on the development of antibodies and chemoenzymatic synthesis techniques.
Latest Patents
Among his latest patents, Chen has developed antibodies specific for d-myo-inositol 1,4,5-trisphosphate. These antibodies were raised by immunizing rabbits with two types of IP3-BSA conjugates, synthesized through covalent coupling of Ins(1,4,5)P3 to a carrier protein via alkyl linkages. The anti-Ins(1,4,5)P3 antibodies were detected using an ELISA method, where Ins(1,4,5)P3 was covalently attached to a microplate well surface. Both antiserum preparations demonstrated specific binding with Ins(1,4,5)P3, and the specificity of these antibodies was enhanced through affinity purification using Ins(1,4,5)P3-agarose chromatography. The affinity-purified antibodies exhibited IC50 values of 12 nM and 730 nM for Ins(1,4,5)P3 and Ins(1,3,4,5)P4, respectively. Additionally, Chen has worked on the chemoenzymatic synthesis of the taxol C-13 side chain, utilizing lipase-mediated enantioselective transesterification to achieve good yields.
Career Highlights
Ching-Shih Chen has held positions at the Board of Governors for Higher Education in the State of Rhode Island. His work has significantly impacted the field of biochemistry, particularly in the development of therapeutic antibodies and innovative synthesis methods.
Collaborations
Chen has collaborated with notable colleagues, including Da-Ming Gou and Yeuk-Chuen Liu, who have contributed to his research endeavors.
Conclusion
Ching-Shih Chen's innovative work in the field of biochemistry and his contributions to antibody development and synthesis techniques highlight his importance as an inventor. His patents and collaborations reflect a commitment to advancing scientific knowledge and therapeutic applications.